Other recommendations for Vegas:
{Stay}
The Nobu Hotel: my new #1 favorite
Palazzo: If you're with a large group, the Palazzo is one of my favorites because all their rooms have a sunken living room with extra space.
The Wynn and Venetian: The other hotels I've tried, which are fine (but for pretty much the same price, go to the Nobu Hotel!)
{Eat}
Shake Shack
Bouchon: in the Venetian and it's great for brunch
Delmonico Steakhouse or Carnevino: both are great steakhouses. Tasty and good service.
Lotus of Siam (off the strip): THE BEST THAI FOOD I'VE EVER HAD. If you have the chance go there and get the prawns. MIND-BLOWING!
{And NEVER go to any of Joel Robuchon's restaurants in the MGM. He should be ashamed at the quality of food and service at those restaurants, and his main, expensive restaurant Joel Robuchon should be stripped of all Michelin stars. It was awful service and mediocre food at ridiculous prices.}
{Do}
Qua Spa at Caesar's: If you're staying at Caesar's (or Nobu) it's only $25 to use their spa pools and steam/sauna/arctic rooms. Might just be the best deal in town. If you purchase a massage, then the use of the spa is free.
My favorite nightclubs: Omnia and XS (in the Wynn). My not-so-favorites are the Marquee (at the Cosmo, get ready to walk up and walk down some major steps in heels ladies) and Hakkasan (at the MGM, super cramped, and poor layout).
Shop at the Forum shops (they range from high-end luxury to an towering 3-storied H&M), the Palazzo (which has Barneys, ok I'm biased about this one), the Fashion Show Mall (though this is like very other mall in America), and the outlets (going to need to catch a taxi for this one).
Downtown Vegas: cheap tables and the Beef Jerky store (for those from Hawaii but don't live in Hawaii who want local snacks). I've also heard that Zappos founder Tony Hsieh has revitalized the area for a more hipster appeal, but I have yet to check it out myself (something to do for the next time I come to Vegas).